Fitness reduces the risk of Heart Diseases

Fitness really help you a lot in whatever health situation you might be in, even if you are born with a heart disease. It would keep your heart healthy, according to a study led by researchers at the Stanford University School of Medicine.

What is a heart disease?

Coronary heart disease—often simply called heart disease—is the main form of heart disease. It is a disorder of the blood vessels of the heart that can lead to heart attack. A heart attack happens when an artery becomes blocked, preventing oxygen and nutrients from getting to the heart. Heart disease is one of several cardiovascular diseases, which are diseases of the heart and blood vessel system. Other cardiovascular diseases include stroke, high blood pressure, angina (chest pain), and rheumatic heart disease.

The study

In one of the largest observational studies on fitness and heart disease, researchers examined data collected from nearly a half-million people in the UK Biobank database. They found that people with higher levels of grip strength, physical activity and cardiorespiratory fitness had reduced risks of heart attacks and stroke, even if they had a genetic predisposition for heart disease.

“People should not just give up on exercise because they have a high genetic risk for heart disease,” said Erik Ingelsson, MD, PhD, professor of cardiovascular medicine. “And vice versa: Even if you have a low genetic risk, you should still get exercise. It all ties back to what we have known all along: It’s a mix of genes and environment that influence health.”

A paper describing the research will be published online April 9 in Circulation. Ingelsson is the senior author. The lead author is Emmi Tikkanen, PhD, a former postdoctoral scholar at Stanford who is now senior data scientist at Nightingale Health Ltd. in Finland.

In order to determine the level of physical activity of the participants, researchers used the data collected from the previous 482,702 participants who underwent grip-strength tests correlating with overall body strength; answered questions about their levels of physical activity; wore accelerometers on their wrists for seven days; and took stationary-cycling tests. Genetic data from 468,095 of the participants was also used in the study.

The researchers found out that the participants who are engage in physical activity are less likely to have cardiovascular outcomes, including coronary artery disease, stroke and atrial fibrillation.

Among those considered at high genetic risk for heart disease, high levels of cardiorespiratory fitness were associated with a 49 percent lower risk for coronary heart disease and a 60 percent lower risk for atrial fibrillation compared with study participants with low cardiorespiratory fitness.

For participants deemed at intermediate genetic risk for cardiovascular diseases, those with the strongest grips were 36 percent less likely to develop coronary heart disease and had a 46 percent reduction in their risk for atrial fibrillation compared with study participants who had the same genetic risk and the weakest grips. Researchers determined various levels of genetic risk according to measurements based on discoveries from genomewide association studies, the most common study design to discover genetic variation associated with disease.

Source: National Heart Lung and Blood Institute, News Medical